First, the engineers must decide what the application
is being designed for... Motocross, Cross Country, or Utility 4x4.
For instance, motocross tires use lower knob depths with each knob spaced close together to allow for a larger tread contact patch along with a light weight 4 PR casing and very sticky rubber compound. there are many jumps so the light weight tire helps the handling as well as reducing rotating wheel weight.
Cross Country (GNCC) tires generally are raced over longer periods of time and over a wide variety of terrain including rocks, tree roots, creek crossing, long up hills and down hills etc... so the tread is designed to have slightly taller knobs so they dig in deeper, more support at the knobs base to improve durability along with a 6 PR casing to protect against punctures and reduce tire roll over on
off camber turns or rutted terrain.